Martínez de Toda, Irene; Rattan, Suresh IS; De la Fuente, Mónica; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-31)
Oxidized, damaged and misfolded proteins accumulate during aging and contribute to
impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular
clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function,
whereas long-lived species show high levels. However, contradictory results exist depending on the
tissue or cell type and it is ...